Versions: 2.50.3, 2.53 (various beta releases)
Windows 10
What will happen is that the graphics just completely stop doing anything, even though I can still hear the game working, and I can still move/attack/etc. Here's a video: https://www.twitch.tv/videos/349620890
Aside from the game graphics not working, none of the menus work either. If I try to close the window, the confirmation dialog doesn't show (even though I think it's probably there).
I haven't found any patterns that cause this to happen. It has happened within 10 minutes of opening the progress, but it has also happened 4 hours+ in.