Anything other than Windows Defender: It's the first thing that I disable on any Win10 machine.
Throwing rocks, is better protection, than that.
Anything is better than WD: It false flags ZC and a bunch of other open-src software and will make you go bonkers. How much software do you download from untrusted sources?
You replied to the OP twice. Just so you know.
Speaking mostly anecdotally here, but maybe 50-60% of the software I use on Windows is open source and I have never, ever had Windows Defender false flag anything I use as malware. Even if it did, it'd be easy to reverse anyway. The only Zelda Classic-related false positive I've gotten is from zcmusic.dll, which a) only happens with older versions of ZC; b) hasn't happened in forever anyway. And all I did then was just told Windows not to treat it as a trojan.
It's fair to say that there's better anti-virus programs, but it's pretty wantonly irresponsible to just tell people that not having an anti-virus is better than Windows Defender. Saffith already touched upon the potential attack vectors that aren't just downloading untrusted executables, and Windows Defender is a good option for most people: Windows Defender is fast, which in my experience Avast tends to cause all sorts of performance issues if it's running. Plus it's free, and most people already have it installed anyway; people can look to see if there's anything better, but it's going to be tough to find anything better that's also free.
It's possible that you're conflating Windows Defender with Windows SmartScreen, which does actually have a tendency to produce false positives if you download a program that's not extremely popular. Not that that's hard to get around, but I wouldn't blame people for disabling SmartScreen specifically.